A modified functional group of chitosan film was successfully prepared. Maleic anhydride (MA) was used to introduce carboxylic functional groups into chitosan film to enhance the drug loading capacity of the film and also control the drug release. The experiment was carried out by adding various amounts of MA into a chitosan solution, followed by loading the drug into the mixed solution. The drug release study was conducted by immersing the chitosan film in phosphate-buffered saline (PBS) solution (pH 7.4) as a body fluid model. This study was carried out in purpose to study the release kinetics of a drug from the modified chitosan film. Hence, the drug release data obtained were correlated with three mathematical models of drug release kinetics: Higuchi's model, Peppas' Model, and First-order model. Finally, the results revealed that the modified chitosan film exhibited a controlled release profile. Among the three mathematical models, the drug release profile from the modified chitosan film was best fitted with the First-order model. Nomenclature C A = Concentration of drug in the film, mg/cm 3 C AL = Concentration of drug in liquid, mg/mL

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Tissue engineering has shown a remarkable result in medical applications. Further exploration, these multidisciplinary fields are also given a possibility as an alternative medication for intervertebral disc (IVD) degeneration. Focusing on the annulus fibrous repair, to improve the mechanical properties of biomaterials, a composite made of chitosan and polycaprolactone (PCL) was developed in this present study. Due to its tuneable properties, the electrospinning-based method was used in the experiment to create the chitosan/PCL composite. Varies concentration of PCL (11, 12, and 13 wt%) and a different ratio of precursors chitosan to PCL (1:1; 1:3; 1:5) were used to optimize the composition of natural and synthetic polymer in the composite nanofibers. The obtained nanofibers were then characterized using Scanning Electron Microscopy (SEM) to observe the morphology, swelling test, Fourier Transform Infrared (FTIR) spectroscopy, and Differential Scanning Calorimetry (DSC). The results show that the increasing concentration and composition of PCL could form the more homogeneous and larger diameter of nanofiber with fewer beads compare to the lower composition of PCL nanofiber. Meanwhile, the swelling percentage decreases by increasing the amount of PCL. FTIR results also show that all samples of composite nanofibers contain both chitosan and PCL.