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The design of new drug candidates that combine anthelmintic and antioxidant actions in one molecule offers a beneficial approach in the treatment of the tissue damages, immune system dysfunction and oxidative stress caused by trichinellosis.

The incorporation of a hydroxyl group in the hydrazide part of a parent molecule which relates to better antioxidant effect in most of the studied systems is associated with higher IC values in all cytotoxicity experiments and relates to the cytoprotective effect against N-methyl-D-aspartate-induced excitotoxicity in SH-SY5Y human neuronal cells.