Textile industries use dyes to color their products and release waste water containing dyes, causing water pollution which is a serious problem for survival of human life on earth. The decolorization of basic turquise blue X-GB (BTB X-GB) 250% and basic blue X-GRRL (BB X GRRL) 250% dyes was examined by advanced (Fenton process) oxidation process. The effects of different parameters (initial dye concentration, pH, concentrations of hydrogen peroxide (H2O2) and reaction time) have been examined and optimum conditions were determined. It has been noted that percentage decolorization of both dyes (50 mg/L) increases with increase in concentration of H2O2. At optimum conditions (pH=3.0, H2O2=4.8 mM, temperature=50°C, time=80 min of BTB X-GB, and pH=5.0, H2O2=5.6 mM, temperature=40°C, time=60 min of BB X-GRRL) the decolorization obtained by Fenton process was 85.83% of BTB X-GB and 74.98% for BB X-GRRL. 1st order, 2nd order and BMG kinetic models were used to analyze the data. BMG model gives us the higher values of correlation coefficients for all data. Results showed that Fe2+/H2O2 are most effective for oxidation treatment of waste water effluents containing dyes as main pollutants.

The aim of this current piece of writing is to draw the attention of readers and researchers toward the natural antioxidants that can take the place of synthetic antibiotics to avoid bacterial resistance and gastrotoxicity/nephrotoxicity. Antioxidants such as polyphenols, vitamins, and carotenoids are the organic compounds mainly extracted from natural sources and dominantly involved in boosting the defense system of organisms. The main public health-related issue over the globe is ever-growing bacterial resistance to synthetic antibiotics, which is being continuously reported during the last decade. Further, the pipeline of the development of new synthetic antibacterial agents to replace the resistant antibiotics in clinical setup is gradually drying up. This scenario originated the concept to revive the interest toward natural antibacterial products due to their chemical diversity, which provide important therapeutic effect and make the microbes unable to copy them for creating resistance. Natural products, especially polyphenols had been seen in antioxidant, antibacterial, anticancer, anti-inflammation, and antiviral activities with encouraging results. In this chapter, we will focus over the role of natural antioxidants as antibacterial agents.

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The development of functional imaging is a promising strategy for diagnosis and treatment of infectious and cancerous diseases. In this study, epirubicin was developed as a [ Tc]-labeled radiopharmaceutical for the imaging of multi-drug-resistant Staphylococcus aureus infections. The labeling was carried out using sodium pertechnetate (Na TcO ; ~370 MBq). The other parameters such as amount of ligand, reducing agent (SnCl .2H O), and pH were optimized. The highest labeling yield ≥96.98% was achieved when 0.3 mg epirubicin, 13 μg SnCl .2H O, and ~370 MBq Na TcO were incubated at pH 7 for 15 min in the presence of ascorbic acid at room temperature. Radiochemical purity, stability, charge, and glomerular filtration rate were studied to evaluate the biological compatibility for in vivo administration. Biodistribution investigations showed radiotracer uptake (13.89 ± 1.56% ID/gm organ) by liver and 7.79 ± 0.38% ID/gm organ by kidneys at 30 min post-injection which promisingly wash out at 24 hr post-injection. Scintigraphy study showed selective uptake in S. aureus-infected tissues in contrast to turpentine oil-induced inflamed tissues. Target-to-non-target ratio (6.7 ± 0.05) was calculated at 1 hr post-injection using SPECT gamma camera. The results of this study reveal that the [ Tc]-epirubicin can be a choice of imaging and monitoring the treatment process of multi-drug resistant S. aureus bacterial infections.

This study focuses on application of advanced oxidation (Photo-Fenton) processes to decolorize Basic Turquise Blue (BTB) X-GB 250% and Basic Blue (BB) X-GRRL 250% dyes. The percent decolorization was studied in terms of effect of variation in intensity of UV light at optimum conditions of all the parameters (pH = 3.0, H2O2 = 4.8 mM, FeSO4 = 1.6 mM, temperature = 50 °C, time = 80 min for BTB X-GB, and pH = 5.0, H2O2 = 5.6 mM, FeSO4 = 2.0 mM, temperature = 40 °C, time = 60 min for BB X-GRRL). Maximum decolorization was obtained at maximum intensity (15660 counts/min) of UV light as 96.17% for BTB X-GB and 88.48% for BB X-GRRL. First order, 2nd order and BMG kinetic models were used to analyze the data obtained for intensity of UV light. BMG model gives us the higher values of correlation coefficients for all data of both the dyes. The results have shown that Photo-Fenton oxidation process is the beneficial and effective for oxidation treatment of waste water effluents containing dyes as main pollutants.