17beta estradiol ameliorates neuroinflammation driven neuropathic pain in chronic constriction injury -induced peripheral neuropathy in rats nafissa telailia 1 , hacène frih 1 , sylvain fisson 2,3,4

The objective of our study is to propose a therapeutic strategy based on the administration of cyclosporine alone, and cyclosporine associated with a sound noise in two batches of animals treated with an immunostimulant Biliated bacillus of Calmette and Guerin, all based on the hypothesis of the central role of neuroimmuno-endocrine regulation loop in disorders related to the administration of cyclosporine. We administered cyclosporine alone (IP) for 8 days, as well as administration of cyclosporine associated with sound noise with food and sugar water and stained in two batches of Biliated bacillus of Calmette and Guerin -treated animals ( in ID), the animals received Biliated bacillus of Calmette and Guerin injections on the 9th day and a reminder on the 27th day. Our results show that intraperitoneal injection of cyclosporine alone (20 mg / kg) causes a significant decrease in testosteronemia associated with a drop in body weight. Similar results were found following administration of cyclosporine associated with sound noise. Conversely, administration of cyclosporine alone and associated with sound noise caused a significant increase in adrenocorticotropic hormone. Indicating that sound noise mimics the effect of cyclosporine in male rats.