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Counterfeit drugs (CDs) continue to cause serious public health problems in many countries around the globe, particularly in the African countries which are their major consumers. Soft penalties for the drug counterfeiters; recent increase in internet commerce; ignorance and lack of effective partnership between drug companies, drug regulatory agencies, law enforcement bodies, customs, among others, have contributed to the rise in counterfeiting menace. However, governments at various levels in some of the affected countries do not accede to the menace of CDs, as they are implementing many strategies through the recent innovations and advancement in technology to curtail it. Nevertheless, there is still needs for taking more rigorous steps to achieve complete eradication of the crime. This review article presented the impact of CDs in the Africa’s quality health-care delivery, with particular attention to the causes, magnitude, and consequences. The review also identifies areas where concerted drug policies and actions are required to eradicate the drug counterfeiting crimes and also provides suggestions to drug’s policymakers and relevant stakeholders that may be useful in making decisions that can safeguard the public from the danger of CDs.

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