The sample size for this study was small. However, based on the encouraging results of this proof-of-concept study, longer duration studies in larger population can be conducted to further confirm these findings. TRIAL REGISTRATION DETAILS: Clinical Trial Registry-India URL: http://ctri.nic.in, Registration Number: CTRI/2009/091/001036.

Parkinson’s disease is often recognised as a motor disease characterised by rest tremor, rigidity, bradykinesia, and postural disturbances. However, there are several non-motor aspects of the disease that are of at least equal importance in the management of patients with Parkinson’s disease. They include depression, cognitive impairment, anxiety, and psychosis among others. It is important to recognise them, as they are common and they contribute significantly to patients’ morbidity, quality of life, and institutionalisation to long term care homes. In addition to the disease duration and severity, other factors including drugs may contribute to their occurrence. Pathogenesis of these aspects is not fully understood, though there has been a significant increase in the knowledge in recent years. Management of these aspects involves a multidisciplinary approach.

Background: Exposure to shift works and especially to night shifts goes against the circadian rhythm of the social man which brings about a multitude of disruptive effects on health such as sleep disturbances, day sleepiness, decreased cognitive performance, fatigue, increased risk of accidents, poor quality of life, and vigilance troubles. Aims and Objectives: Evaluate sleep quality and its association with cognition among hospital shift working nurses. Materials and Methods: This is a cross-sectional study to investigate the quality of sleep and association with cognition among shift working nurses. 50 of each night, day shift workers and those who never exposed to shift work participated in this study (n = 150). Sleep quality and seven domains of sleep, subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleeping medication, and daytime dysfunction were assessed using the Pittsburgh sleep quality index (PSQI) questionnaire. Cognitive performance was ev aluated using reaction time (RT) test. Inter-and intra-group analysis was done using ANOVA and Tukey's post hoc analysis using SPSS 20 software. Results: Global score of PSQI, subjective sleep quality, sleep duration, and sleep medication was statistically high among night shift nurses suggesting poor sleep quality compared to day shift and controls (P = 0.021, P = 0.021, P = 0.00, P = 0.00). Intragroup analysis shows that simple visual RT and choice visual RT are significantly high in night shift nurses when compared to day shift and controls (P = 0.00). Positive correlationwas found between global PSQI score with RT (r = 0.096). Conclusion: Night shift workers have poor quality of sleep when compared to day shift workers and those who were never exposed to shift work. Our study also concludes that poor quality of sleep has strong association with reduced cognition.

No abstract