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Aims: The aim of this is study was to evaluate the usage of fresh frozen plasma (FFP) according to indications and to reduce inappropriate usage. Methods: A two year retrospective study was conducted in Medical College Hospital blood bank. Based on the guidelines published by College of American Pathologists, National Health and Medical Research Council and Australasian Society for Blood Transfusion FFP usage were categorized into appropriate and inappropriate. Pre and post-transfusion INR/PT were recorded and the effect of FFP were studied in patients who received FFP. Results: During two years 1884 units of FFP were used for 945 patients. Only 454 (48%) requests were appropriate and 491 (52%) were inappropriate requests. Absence of bleeding or surgical intervention was the commonest reasons for inappropriate FFP use. Mean improvement in the pre-transfusion INR per unit of FFP was 0.75 (median 0.56, range 0–3.7) of which 33% showed significant improvement in the pre-transfusion INR. Conclusions: Our results showed a 48% appropriate and 52% inappropriate use of FFP in patients. Inappropriate FFP use could be reduced by educating the staff, by establishing the hospital transfusion guidelines, by regular evaluation of requistions and by conducting awareness programme among clinicians.

Aims: Dengue infection is a global health problem affecting an estimated population of 50–100 millions every year. Thrombocytopenia is an essential diagnostic criteria. Platelet transfusion is given in those patients who have haemorrhagic manifestations along with thrombocytopenia. The aim of the study was to know the effectiveness of platelet transfusion in dengue patients. Methods: The study was conducted during the epidemic of dengue fever from July 2011 to October 2011. Serologically confirmed dengue cases were included in the study. Results: Two hundred thirty two patients were positive for dengue serological tests of which 195 (84.2%), 35 (15%), 2 (0.8%) were DF, DHF DSS respectively. One hundred eighty two (78.4%) patients received platelet transfusion. One hundred eighteen (51%) cases received single unit of platelet transfusion though platelet count was between 0.2–1.0x10x105/mm3. Sixty four (27.5%) patients who had platelet count <0.2x105/mm3 received multiple platelet transfusions. The patient who received multiple platelet transfusion of 10–12 units showed post transfusion increment of >0.5x105/mm3 and they were discharged after 5–6 days of hospitalization. Conclusions: This study suggests that 51% platelet transfusions are inappropriate and it is more effective when it is given to patients with platelet count <0.2x105/mm3. Platelet transfusion practice should be based upon platelet count and haemorrhagic manifestations as this decreases hospitalization of the patients and complications of dengue.