A six-year-old intactfemale domestic dwarf rabbit (Oryctolagus cuniculus) was presented with an onset of persistent lethargy, inappetence, decreased urination and subcutaneous, fluctuating swelling at the left side of the anal orifice. Physical examination confirmed high-grade cachexia, general muscular atrophy and perineal repositionable swelling. Reposition was associated with spontaneous urination. Rectal examination revealed dilated pelvic muscles. Radiographs demonstrated an approximately 4×5×3 cm structure of soft tissue opacity with radiopaque content. Needle aspiration exposed cream-coloured fluid identified as urine by cytology and refractometer. In summary, all clinical findings supported the diagnosis of a bladder herniation through the pelvic muscle into the perineal region. The proposed pathogenesis might be persistent inappetence that resulted in high-grade cachexia and generalised muscle atrophy, followed by prolapse of the bladder. This is the second published report describing unilateral perineal herniation and incarceration of the bladder in an intactfemale rabbit.