is a progressive genetic disease characterized by a neuroectodermal abnormality, mainly affecting the skin, nervous system, bones, eyes, and possibly other organs. This disorder has been divided into three forms: Neurofibromatosis type 1, Neurofibromatosis type 2, and Shwannomatosis (Jett & Friedman, 2010).Neurofibromatosis 1 (NF1; OMIM# 162200) is one of the most common autosomal dominant genetic diseases with a worldwide incidence of about 1:3500 (Jett & Friedman, 2010;Mao et al., 2018). In 95% of cases, clinical diagnosis

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