Objective: To determine the prevalence and associated risk factors for musculoskeletal pain among medical students in Saudi Arabia. Method: A cross-sectional analysis for one Saudi medical school in 2015-2016 academic year.Themain outcomes were measured byThe Nordic Musculoskeletal Questionnaire (NMQ) which was used to screen for pain in different anatomic joints during the past week and past year. Another questionnaire was developed to assess for contributing factors for the pain. Result: 849 medical students were analyzed with a response rate (73.31 %.). There were57.85% of the students suffering of musculoskeletal pain in the past week, and 43.47% in past year. There is a higher prevalence among female medical students with p value <0.01. Previous trauma, family history of trauma, high computer hours use, being in clinical years, and high BMI were the main factors contributing to MSP in this study. Conclusion:The study demonstrates a very high prevalence of musculoskeletal pain medical students which may affect the lifestyle and academic performance in medical schools.Copy Right, IJAR, 2017,. All rights reserved. …………………………………………………………………………………………………….... Background:-Musculoskeletal pain (MSP) which includes commonly low back pain, shoulders pain and neck pain is a common heath problem that affect both male and female. World-wide estimates of lifetime prevalence of low back pain (LBP) vary from 50 to 84 % and 20-30% at any given time [1]. Musculoskeletal pain affects people's mood leading to depression, anxiety, irritability, poor social interactions, and lower overall health status, and that can limit the individual productivity, induces stress and it is socially costing in terms of health care. Although the Musculoskeletal pain represented as a common occupational problem it may affects younger population like school and university students who have not yet entered their working life. Moreover, previous studies have demonstrated a higher prevalence of MSP among medical and dental students compared to other university students. Several studies investigated the prevalence and factors associated with MSP among medical students. However, there are no previous studies have been conducted among medical students in Saudi Arabia. The authors aim in this study to measure the prevalence of this health problem among medical students in Umm Al-Qura University, College of Medicine (UQUMed) in Saudi Arabia, compare it with other investigated risk factors in literatures, and look for other possible factors that may contribute to MSP.