HighlightsInserting tPA leader sequence enhanced humoral responses of ChAdOx1 MERS.ChAdOx1 MERS elicited cellular immunity and neutralising antibodies.ChAdOx1 MERS responses were boosted by MVA MERS.Immunogenicity of a single dose of ChAdOx1 MERS was equivalent to 2 doses of MVA MERS.In MVA, F11 promoter enhanced cellular, but not humoral, immunogenicity, comparing to mH5 promoter.
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