ObjectivePostoperative atrial fibrillation (PoAF) is a common complication after
coronary artery bypass grafting (CABG). The aim of the present study was to
evaluate the association between development of PoAF and vitamin D levels in
patients undergoing isolated CABG.MethodsThis prospective randomized clinical trial was conducted on the patients with
isolated CABG. The study was terminated when 50 patients in both PoAF(+)
group and PoAF(-) group were reached. Development of AF until discharge
period was assessed. Vitamin D level was measured immediately after AF; it
was measured on the discharge day for the patients without PoAF. Predictive
values of the independent variables were measured for the development of
PoAF.ResultsThe groups were separated as PoAF(-) group (66% male, mean age
58.18±10.98 years) and PoAF(+) group (74% male, mean age
61.94±10.88 years). 25(OH) vitamin D level (OR=0.855, 95% CI:
0.780-0.938, P=0.001) and > 65 years (OR=3.525, 95% CI:
1.310-9.483, P=0.013) were identified as an independent
predictor of postoperative AF after CABG surgery in multivariate analysis.
The cut-off level for 25(OH) vitamin D level in receiver-operating
characteristic curve analysis was determined as 7.65 with sensitivity of 60%
and specificity of 64% for predicting PoAF (area under the curve: 0.679,
P=0.002).ConclusionVitamin D level is considered an independent predictor for development of
PoAF. Lower vitamin D levels may be one of the reasons for PoAF.
Objective: Postoperative atrial fibrillation (PoAF) is a common complication after coronary artery bypass grafting (CABG). The aim of the present study was to evaluate the association between development of PoAF and vitamin D levels in patients undergoing isolated CABG.Methods: This prospective randomized clinical trial was conducted on the patients with isolated CABG. The study was terminated when 50 patients in both PoAF(+) group and PoAF(-) group were reached. Development of AF until discharge period was assessed. Vitamin D level was measured immediately after AF; it was measured on the discharge day for the patients without PoAF. Predictive values of the independent variables were measured for the development of PoAF.Results: The groups were separated as PoAF(-) group (66% male, mean age 58.18±10.98 years) and PoAF(+) group (74% male, mean age 61.94±10.88 years). 25(OH) vitamin D level (OR=0.855, 95% CI: 0.780-0.938, P=0.001) and > 65 years (OR=3.525, 95% CI: 1.310-9.483, P=0.013) were identified as an independent predictor of postoperative AF after CABG surgery in multivariate analysis. The cut-off level for 25(OH) vitamin D level in receiver-operating characteristic curve analysis was determined as 7.65 with sensitivity of 60% and specificity of 64% for predicting PoAF (area under the curve: 0.679, P=0.002). Conclusion: Vitamin D level is considered an independent predictor for development of PoAF. Lower vitamin D levels may be one of the reasons for PoAF. Abbreviations, acronyms & symbols 25(OH) vitamin D ACE AF ARB CABG CI COPD CPB ECG ICU OR PoAF RAAS ROC = 25-hydroxy vitamin D = Angiotensin-converting enzyme = Atrial fibrillation = Angiotensin receptor blocker = Coronary artery bypass grafting = Confidence interval = Chronic obstructive pulmonary disease = Cardiopulmonary bypass = Electrocardiography = Intensive care unit = Odds ratio = Postoperative atrial fibrillation = Renin-angiotensin-aldosterone system = Receiver-operating characteristic curve Brazilian Journal of Cardiovascular Surgery Braz J
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.