Some studies with Western men have shown promising results for the efficacy of cognitive behavior sex therapy (CBST) in the treatment of erectile dysfunction. The two randomized controlled trials were conducted to assess the efficacy of CBST as a treatment of choice for young men with non-organic erectile dysfunction (NOED). The two randomized controlled trials were run to assess the efficacy of CBST and integrated treatment approaches for the treatment of NOED in young Pakistani men. The two studies were registered with ClinicalTrials.gov vide No. NCT04179747 and NCT04126252. The sex therapy techniques were combined with cognitive behavior therapy and mindfulness to develop an indigenous approach for the treatment of NOED in young Pakistani men. The CBST significantly improved International Index of Erectile Functioning-5 scores in two studies. The CBST also decreased depression scores associated with NOED. The CBST is a treatment of choice for young Pakistani men with NOED. The CBST is also significant in improving the mental health conditions associated with NOED.