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Background Many clinically indicated skin biopsies show minimal histological changes referred to as “invisible dermatoses.” They pose a challenge to general pathologists and dermatopathologists. This study determines the discrepancy between the general pathologists' diagnosis and the dermatopathologist's diagnosis and helps define a pathway for reaching the correct diagnosis. Methods In total, 81 skin cases were selected from a tertiary hospital pathology department. They were diagnosed by general pathologists as “no specific diagnosis,” or “minimal pathologic changes.” These cases were reviewed carefully and diagnosed by a dermatopathologist. His diagnoses were compared with the original diagnoses. Results Out of the 81 cases, 43 cases (53%) were reported by the dermatopathologist to have a specific diagnosis while 38 cases (46.9%) remained nonspecific. Both inflammatory and neoplastic diagnoses of potential clinical significance were made in the first group of 43 cases. The remaining 38 cases with nonspecific results were due to inadequate biopsy, inactive lesions or inadequate clinical data. Conclusion “Invisible dermatoses” describes skin diseases with clinically evident but histologically hidden changes. They are difficult cases for general pathologists and dermatopathologists to diagnose. Hence, it is important to be aware that minor changes on a skin biopsy do not mean it is disease‐free.

LN is a very common finding in TRI-positive kidney biopsies. Active LN and chronic LN are the more common classes of TRI-positive LN kidney biopsies, than pure membranous (Class V) LN. TRI positive kidney biopsies without LN are commonly found in diabetic nephropathy, connective tissue disorders and immune mediated GN's. This study highlights this finding in our patients cohort in opposition to what has been reported in the literature.