The gallbladder is a small pear-shaped organ that lies underneath the liver and stores bile. Despite being a small organ there is a high chance of malignancy reported. The absence of the serosa layer, proximity to critical adjoining structures, and easy extension to lymphatics makes it vulnerable for early dissemination. Often, patients present in an advanced stage of the disease, with disseminated metastasis being reported in the range of 65% to 82%, for hematological metastasis and 91% to 94% for lymphatic metastasis, respectively [1,2]. Although its incidence in Western countries is less, it is quite prevalent in Asian counties with a high prevalence seen amongst obese females with a personal or family history of gallstones and ill-defined genetic variants [3]. According to GLOB-OCAN 2020 data [4], gallbladder cancer (GBC) is the 23rd most incident but 20th most deadly cancer worldwide.Depending upon the stage of the disease, surgery, radiotherapy (RT), and chemotherapy are the modalities of treatment used for Gallbladder cancer is a highly malignant disease with a poor prognosis. It is the most common cancer of the biliary tract pathway. Although surgery remains the treatment of choice for early-stage disease, majority of the patients presents in locally advanced, unresectable and metastatic stage of the disease. Radiotherapy and chemotherapy thus form an integral part of management for these locally advanced staged patients. The role of radiation though has been advocated in gallbladder cancer, majorly in the adjuvant setting, its role in neoadjuvant and palliative settings remains in an evolving phase. The article thus aims to review and update the existing literature regarding the role of radiation therapy in gallbladder cancer.