Review question / Objective: Clinically, the knee is the most common site of OA, followed by the hand and hip. The basic research question of our study is: Among patients with osteoarthritis knee, aged 40 and above, is total knee replacement with post-surgical management associated with better functional outcomes and quality of l i f e c o m p a r e d t o n o n -s u r g i c a l INPLASY 1 International Platform of Registered Systematic Review and Meta-analysis Protocols INPLASY PROTOCOLProtocol for A systematic review of utility values of total knee replacement vs non-surgical management among 40 years and above population with knee osteoarthritis

Review question / Objective: Clinically, knee is the most common site of OA, followed by the hand and hip. The main research question is what are different costing methodologies used and its quality in studies related to cost effectiveness of TKR compared to non-surgical treatment procedures. Based on this review question, the following objectives are proposed: 1. To assess different methodologies, scope and quality of studies related to cost effectiveness of TKR compared to non-surgical management. 2. To synthesize evidence of TKR cost and compare the variations across different countries. Information sources: All sources with information on TKR, economic evaluations and non-surgical management namely journals, handbooks, internet sources, published conference abstracts, thesis, and electronic databases will be searched extensively.