The support systems for assisting clinical decision highly improve the quality and efficiency of the therapeutic and diagnostic treatment in medicine. The proper implementation of such systems can emulate the reasoning of health care professionals in such a way that suggest reasonable decisions on patient treatment. The fuzzy logic system can be considered as one of the efficient techniques for converting a complex decision tree that usually facing the physician into artificial intelligent procedure embedded in a computer program. So many properties in fuzzy logic system that can facilitate the process of medical diagnosis and therapeutic management. In this paper, a system for therapeutic management of hypertriglyceridemia was efficiently realized using a fuzzy logic technique. The obtained results had shown that the proposed fuzzy logic contributes a reliable managing procedure for assisting the physicians and pharmacist in treating the hypertriglyceridemia. Many different hypertriglyceridemia treatment cases showed a perfect matching decision between the standard guidelines and that given by the proposed system.