A BSTRACT Preserving the natural dentition in its normal form and function is one of the major goals of endodontic treatment. Re-establishing the lost vitality and development of root maturation in immature permanent teeth with pulp necrosis/apical periodontitis is quiet challenging clinically. The very basis of regenerative endodontics relies on the concept of tissue engineering using stem cells, biomimetic scaffold, and bioactive growth factors to regenerate the pulp tissue damaged by microbial infection, injury, or developmental defects. In clinical endodontics, this approach is referred to as a “paradigm shift.” Even though repair instead of true regeneration is achieved with current protocols, it is hoped that further research in the area of stem-cell-based tissue engineering will allow for true regeneration and improved treatment outcomes. The aim of this review is to discuss about the various aspects of regenerative endodontics, current clinical protocols, and the future of pulp regeneration techniques.

A BSTRACT Aim: The aim of this study was to evaluate in vitro the efficacy of pantoprazole, a proton pump inhibitor, alone, and in combination with calcium hydroxide against Enterococcus faecalis , a star survivor in endodontic pathology. Materials and Methods: Teeth were inoculated with E. faecalis strains MTCC 439 and were divided into groups. Group 1 used saline as the negative control, Group 2 used calcium hydroxide, Group 3 used pantoprazole alone, and Group 4 used calcium hydroxide along with pantoprazole. They were incubated and dentine harvesting was performed. Colonies were counted using a digital counting machine. Data were statistically analyzed. Results: Group 4 was found to be the most effective against the pathogen. Discussion: This study indicates that the association of calcium hydroxide with the proton pump inhibitor pantoprazole can be successfully used as an intracanal medicament against E. faecalis .

Introduction: The aim of this study was to compare the shear bond strengths of zirconia to dentin using two resin-based luting cements and a resin-modified glass-ionomer cement (RMGIC). Materials and Methods: Thirty six zirconia blocks of 2 mm × 3 mm × 5 mm were milled and luted to the exposed dentin surfaces and grouped into three according to the cement used for luting: Group I – luted with Panavia F2.0, Group II – luted with RelyX U200, and Group III – luted with FujiCEM. After thermocycling, specimens were subjected to shear bond testing in an Universal Testing Machine (UTM). Data analysis using Kruskal–Wallis ANOVA and post hoc Mann–Whitney U -test with P < 0.05 was done. Results: Mean bond strengths were of the order Panavia F2.0 (5.99 MPa)>RelyX U200 (4.79MPa)>FujiCEM (1.59 MPa). Maximum failures were at the zirconia-cement interface and were adhesive in nature. Conclusions: It can be concluded with the study that there is a better bonding of zirconia to dentin with resin-based luting cements than a RMGIC. The single-step resin-luting cement RelyX U200 produced comparable bond strength to that of a multistep Panavia F2.0.

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