Background: Adverse drug reaction (ADR) is any undesirable or unintended consequence of drug administration. Pharmacovigilance is the science and activities concerned with the monitoring of the safety of drugs. Underreporting of ADRs is a major challenge for pharmacovigilance programs. Aims and Objectives: (1) To assess knowledge, attitude, and practice of pharmacovigilance among health-care professionals working in tertiary care hospital. (2) To create awareness and strengthen the ongoing pharmacovigilance activities among health-care professionals. Materials and Methods: This is a questionnaire-based cross-sectional study conducted at BIMS Hospital Belagavi, Karnataka, India; A pre-designed and structured multiple choice questionnaire containing 23 questions was used to assess knowledge of pharmacovigilance, attitude toward ADR reporting, the practice of pharmacovigilance and their suggestions to improve ADR reporting (Q no.23). Questionnaire was distributed among 150 doctors working in the hospital. Results: 133 doctors responded to the questionnaire. 124 (93.23%) were aware of the purpose of reporting ADR. 55 (41.35%) had an opinion that ADR reporting should be voluntary. 46.62% of subjects believed that the identity of the reporter can be revealed. 86.47% of doctors had seen patients experiencing ADR, and 27.07% maintained a record of it and reported it to the ADR monitoring center. To improve the knowledge, attitude, and practice, the majority of participants suggested conducting training and continuing medical education for all health professionals. Conclusion: Doctors have good knowledge and attitude towards pharmacovigilance program, but there is underreporting of ADRs. Creating awareness among all health-care professionals, motivating them to report ADRs through training, and providing ADR reporting forms to hospital wards may improve the outcome.

Here, we report a case of a 30-year-old male who was prescribed eperisone hydrochloride for body pain and loose stools after which he developed severe maculopapular rash. Eperisone hydrochloride is an analgesic and antispastic drug used for spastic diseases such as spastic paralysis in cerebrovascular diseases, cervical spondylosis, and periarthritis. The drug is marketed in most of the Asian countries including India, but it is not licensed. Studies show the history of hypersensitivity in other countries, but this is the first reported case in India.

Background: Liver abscesses, both amoebic and pyogenic, continue to be an important cause of morbidity and mortality in tropical countries. Pyogenic liver abscess is a serious, life-threatening condition with a high mortality rate that represents a diagnostic and therapeutic challenge. In India, due to poor sanitary condition and a lower socioeconomic status, amoebiasis is endemic and amoebic liver abscess accounts for 3-9% of all cases of amoebiasis. Aim and objectives of current study was to study demographic profile in patients of amoebic and pyogenic liver abscesses. Methods: A detailed history was taken from each of these patients and all of them were subjected to a through clinical examination. Results: The highest incidence occurred in the age group 31-50 years; males were more commonly affected than females. Fever and pain abdomen were the most consistently occurring symptoms. All the patients with liver abscess had abdominal tenderness. 17 patients (74%) with liver abscess were alcoholics. 8 patients (80%) with amoebic liver abscess were alcoholic as compared to 9 patients (69%) in pyogenic liver abscess. Conclusions: Pyogenic organisms were most common cause of liver abscess.