Background: Adherence to diet and drugs, blood glucose monitoring, foot care, exercise and early recognition of the complications, are the crucial elements for tertiary prevention of Diabetes Mellitus. Non compliance can lead to poor glycemic control which can eventually aggravate complications and lead to disability and mortality. This study aimed  at estimating prevalence of non-adherence and identify perceptions and practices associated with non-adherence.Materials and Methods: A cross sectional study was conducted in a primary care clinic in a disadvantaged community Hundred patients with Diabetes were recruited and interviewed using a semi-structured questionnaire.Results: Non adherence rate was 30%. Those who are unable to remember multiple doses (37.5%) were 2.77 (95% CI: 0.94-8.15) times more likely to non-adhere to the treatment than those who are able to remember multiple doses (16.7%).Similarly Patients who often discontinued medications and switched over to alternative system medicines tended to be non- adherent 8.5 (95% CI:1.6- 45.0) times more than those who continued treatment without interruption. Non adherence was not associated with age, gender, education level, and cost of medication and duration of diabetes. People who were illiterate and elderly did not know the consequences of missing doses and stopped medications when they felt better as well as resorted to traditional medicinesConclusions: Counselling sessions should focus on perceptions and ideas about diabetes. Innovative health education modalities have to be developed for illiterate and elderly people.Asian Journal of Medical Sciences Vol.7(5) 2016 106-109