This study sought to discover the potential sources of occupational stress in the Ghanaian Banking Sector and their impact on employee performance. The quantitative methodology was employed using survey instrument. Convenience sampling was used to select four top performing banks listed in the Ghana club 100 rankings. Approximately 320 respondents were selected for the study. Occupational stress had a negative significant relationship with employee performance. However occupational role was positively related with employee performance, on the other hand, personal strain was found to be a potential source of occupational stress for bankers which reduced their ability to perform. Coping strategy served as a moderator that reduced the influence of occupational stress on bankers' performance. The study concludes that, the impacts of occupational stress on bankers' performance are not necessarily negative; this is also seen to be very important in the workplace.