Burkitt lymphoma (BL) and Burkitt-like lymphomas (BLL) are clinically and biologically aggressive B-cell malignancies. Brief-duration, high intensity multidrug regimens with central nervous system (CNS) prophylaxis have proven to be effective, with published series of adult patients documenting complete response (CR) rates of 80 to 100 percent and 2-year event-free survival (EFS) rates ranging from 60 to 90 percent. Based upon the known sensitivity of BL to cyclophosphamide and favorable results reported from the Dana Farber Cancer Center using high-dose CHOP in diffuse aggressive lymphomas, we tested a regimen designed to maximize the administered dose of cyclophosphamide while eliminating other agents commonly used in BL protocols. Eleven patients with Burkitt or Burkitt-like lymphoma were treated with 4 cycles of a 5-drug regimen, called high-dose CHOP, which contains a cyclophosphamide dose of 4 gm/m2 with each cycle. Intrathecal methotrexate and midcycle high-dose methotrexate were added as CNS prophylaxis. Ten patients achieved a complete response (91 percent) and with a median follow up of 38 months, the 3-year EFS is 64 percent and the 3-year overall survival (OS) is 72 percent. Three patients recurred after the achievement of a CR. Treatment-related toxicities included myelosuppression, neutropenic fevers/infections, and tumor lysis syndrome requiring hemodialysis in 2 patients. There were no treatment-related deaths and none of the patients had to discontinue therapy secondary to toxicity. In conclusion, the high-dose CHOP with midcycle methotrexate regimen produces response rates and EFS rates comparable to other regimens, with an acceptable toxicity profile. Utilization of high dose cyclophosphamide may eliminate the need for several other agents in Burkitt lymphoma regimens.

. Using portfolio reflections to re-form instructional programs and build curriculum. English Journal, 83(7), 71.

Numerical instabilities hamper the computer simulation of axially symmetric, three-dimensional transient discharges from proceeding (Davies et al 1977).In the present paper, a method is presented in which suppression of the instabilities is attempted by avoiding numerical differentiation. The results when the present method is applied to simulation of a narrow, high-overvoltage discharge observed by Chalmers et al (1972) show that this method enables one to trace the cathode streamer reaching the cathode and the subsequent fronts propagating. The formation of the so-called radial constriction of the streamer is discussed.

What makes a man—or the public memory of a man—into a a legend? The Western world has always had legendary heroes, men who in life waged vigorous campaigns against terrifying odds, and who, in death, bear reputations burnished and embellished and gloriously expanded by the stories their admirers tell. Dietrich of Berne, Frederick Barbarossa, Alexander of Macedon, Charlemagne, the Cid, Russia’s Prince Igor, Cordoba’s Great Captain, and others, live on in legend centuries after their physical lives ended. The stories of these heroes are told in sagas, epics, and lays, in ballads and folksongs, romances and myths. There are also heroes more newly-made. Their stories are broadcast through the media of twentieth-century communication: popular biographies, historical fiction, diplomatic telegrams, reports of senatorial committees, newspaper accounts, magazine articles, motion pictures. Mexico provided the pre-eminent legendary hero of modern times: Pancho Villa.

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