There is a need for improved tracheostomy education among pediatric health care providers. Incorporation of patient-simulation into a tracheostomy educational program was effective in improving knowledge, confidence, and skills. Pediatr Pulmonol. 2016;51:696-704. © 2015 Wiley Periodicals, Inc.

Previous radioligand binding studies have demonstrated human platelet serotonin2A (5‐HT2A) receptor binding sites. Pharmacological similarities between platelet and frontal cortex 5‐HT2A receptor binding parameters have been demonstrated. However, it is not clear whether the platelet 5‐HT2A receptor primary structure is identical to that of the brain receptor. Three overlapping cDNAs were obtained to span completely the coding region of the 5‐HT2A receptor. These clones were sequenced with external and internal primers. The nucleotide sequence of human platelet 5‐HT2A cDNA was identical to that reported for the human frontal cortex 5‐HT2A receptor, except for nucleotide 102 (T → C), which has been reported to represent a normal DNA polymorphism that does not alter the amino acid sequence. This finding may have implications in the study of neuropsychiatric disorders for which altered platelet 5‐HT2A receptor binding has been demonstrated.

This study shows that helicopter emergency medical services do not have an inherent adverse effect on outcome in a mouse model of ischemic stroke with reperfusion. These results endorse the safety of the practice of using helicopter emergency medical services in stroke patients. The observed potential synergistic effect of helicopter-induced factors, such as vibration and changes in altitude, with reperfusion merits further exploration in animal experimental models and in stroke patients.

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