Cs WO nanorods coated with polyelectrolyte multilayers are developed as "four-in-one" multifunctional nanomaterials with significant potential for computed tomography/photoacoustic tomography bimodal imaging-guided photothermal/photodynamic cancer treatment.

A theranostic system of image-guided phototherapy is considered as a potential technique for cancer treatment because of the ability to integrate diagnostics and therapies together, thus enhancing accuracy and visualization during the treatment. In this work, we realized photoacoustic (PA) imaging-guided photothermal (PT)/photodynamic (PD) combined cancer treatment just via a single material, MoO quantum dots (QDs). Due to their strong NIR harvesting ability, MoO QDs can convert incident light into hyperthermia and sensitize the formation of singlet oxygen synchronously as evidenced by in vitro assay, hence, they can behave as both PT and PD agents effectively and act as a "dual-punch" to cancer cells. In a further study, elimination of solid tumors from HeLa-tumor bearing mice could be achieved in a MoO QD mediated phototherapeutic group without obvious lesions to the major organs. In addition, the desired PT effect also makes MoO QDs an exogenous PA contrast agent for in vivo live-imaging to depict tumors. Compared with previously reported theranostic systems that put several components into one system, our multifunctional agent of MoO QDs is exempt from unpredictable mutual interference between components and ease of leakage of virtual components from the composited system.

In this manuscript, four common transition-metal derived metal-organic frameworks have been extensively investigated as heterogeneous catalyst supports for Knoevenagel condensation reactions. A simple post-synthetic modification strategy was employed for the rapid and facile introduction of a primary alkyl amino group. The resulted novel MOF-RNH 2 catalysts showed greatly enhanced Knoevenagel condensation reactivities towards a variety of aldehyde electrophiles. IRMOF-3 proved to be an unsuitable heterogeneous catalyst support due to its fragile nature upon treatment with base. The novel zirconium based UiO-66-NH -RNH 2 and chromium based Cr-MIL-101-NH-RNH 2 materials showed excellent catalytic reactivities, while being highly convenient to synthesize. The basic catalytic activity was further extended to the Henry reaction and excellent catalytic reactivity was achieved. The size-selectivity was also studied to show the Knoevenagel condensation occurred inside of the porous structure of the MOF catalyst. The recycling properties of zirconium, aluminum and chromium derived MOFs were evaluated and zirconium based UiO-66 and chromium based Cr-MIL-101 showed excellent catalytic efficiency after five reaction cycles.

No abstract