Future research needs to explore the efficacy of interventions on multiple clinical outcomes and which combination of interventions (components) would have the most significant effects when using CBT. The generalization of treatment effects in different countries and carers of different types of dementia also need to be addressed. More research is needed to test the efficacy of modern forms of CBT, such as ACT.
This meta-analysis examined the prevalence of depression and burden among informal caregivers of people with dementia (PwD) and compared the prevalence of depression between male and female, and spousal and non-spousal, caregivers. The quality of studies was evaluated and moderator variables explored. A search of six electronic databases (PsycARTICLES, PsycINFO, MEDLINE Complete, SCOPUS, Web of Science and ProQuest) was conducted from the first available date to the 31st October 2017. Inclusion criteria involved observational studies that detailed the prevalence of burden or depression among informal caregivers of PwD. Forty three studies were examined with a total of 16 911 participants. The adjusted pooled prevalence of depression was 31.24 per cent (95% CI 27.70% to 35.01%) and burden was 49.26 per cent (95% CI 37.15% to 61.46%), although heterogeneity among prevalence estimates was high. Depression prevalence estimates differed according to the instrument used and continent in which the study was conducted.The odds of having depression were almost one and a half times higher in female compared to male caregivers. No significant difference was observed between spouses and non-spouses.Most studies had a medium risk of bias. The results indicate a great need within this population for interventions that are effective at reducing burden and depressive symptoms. It therefore appears imperative for dementia services that are not providing interventions targeting these difficulties to do so.
The low attrition and moderate to large effects suggest that MABIs are acceptable and beneficial for informal caregivers of PwD. The lack of significant moderators could advocate services using more cost-effective forms of MABIs. Further higher-quality research is needed to improve the robustness of the evidence base and enable a meta-analysis to thoroughly examine and quantify moderator variables.
This overview aimed to systematically synthesize evidence from existing systematic reviews to signpost practitioners to the current evidence base on nonpharmacological interventions to improve depression, anxiety, and quality of life (QoL) in people with dementia and to discuss priorities for future research. The databases MEDLINE, PsycINFO, Scopus, and Cochrane Central Register of Controlled Trials were searched in August 2017 with an updated search in January 2019. Fourteen systematic reviews of randomized controlled trials of nonpharmacological interventions were identified. Dementia stage was rated moderate or severe in the majority of the reviews and type of dementia varied. Interventions reported to be effective were cognitive stimulation (QoL: standardized mean difference [SMD] = 0.38), music-based therapeutic interventions (depression: SMD = −0.27, anxiety: SMD = −0.43, QoL: SMD = 0.32), and psychological treatments (mainly cognitive behavior therapy; depression: SMD = −0.22, anxiety: MD = −4.57). Although health-care professionals are recommended to continue using these approaches, future research needs to focus on the type and form of interventions that are most effective for different stages and types of dementia.
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