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Many different types of similarity coefficients have been described in the literature. Since different coefficients take into account different characteristics when assessing the degree of similarity between molecules, it is reasonable to combine them to further optimize the measures of similarity between molecules. This paper describes experiments in which data fusion is used to combine several binary similarity coefficients to get an overall estimate of similarity for searching databases of bioactive molecules. The results show that search performances can be improved by combining coefficients with little extra computational cost. However, there is no single combination which gives a consistently high performance for all search types.

We discuss the size-bias inherent in several chemical similarity coefficients when used for the similarity searching or diversity selection of compound collections. Limits to the upper bounds of 14 standard similarity coefficients are investigated, and the results are used to identify some exceptional characteristics of a few of the coefficients. An additional numerical contribution to the known size bias in the Tanimoto coefficient is identified. Graphical plots with respect to relative bit density are introduced to further assess the coefficients. Our methods reveal the asymmetries inherent in most similarity coefficients that lead to bias in selection, most notably with the Forbes and Russell-Rao coefficients. Conversely, when applied to the recently introduced Modified Tanimoto coefficient our methods provide support for the view that it is less biased toward molecular size than most. In this work we focus our discussion on fragment-based bit strings, but we demonstrate how our approach can be generalized to continuous representations.

Abstract-Plagiarism can be of many different natures, ranging from copying texts to adopting ideas, without giving credit to its originator. This paper presents a new taxonomy of plagiarism that highlights differences between literal plagiarism and intelligent plagiarism, from the plagiarist's behavioral point of view. The taxonomy supports deep understanding of different linguistic patterns in committing plagiarism, for example, changing texts into semantically equivalent but with different words and organization, shortening texts with concept generalization and specification, and adopting ideas and important contributions of others. Different textual features that characterize different plagiarism types are discussed. Systematic frameworks and methods of monolingual, extrinsic, intrinsic, and cross-lingual plagiarism detection are surveyed and correlated with plagiarism types, which are listed in the taxonomy. We conduct extensive study of state-of-the-art techniques for plagiarism detection, including character n-gram-based (CNG), vector-based (VEC), syntax-based (SYN), semantic-based (SEM), fuzzy-based (FUZZY), structuralbased (STRUC), stylometric-based (STYLE), and cross-lingual techniques (CROSS). Our study corroborates that existing systems for plagiarism detection focus on copying text but fail to detect intelligent plagiarism when ideas are presented in different words.

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