BACKGROUND AND AIMS: Percutaneous nephrolithotomy (PCNL) is a safe and effective endourologic procedure in patients with renal calculi. Though it is less painful than open surgery, effective postoperative analgesia is required to reduce the pain around the nephrostomy site. Objectives of this study are to compare and evaluate the peritubal infiltration of bupivacaine, ropivacaine, and placebo from renal capsule to skin along the nephrostomy tract for postoperative analgesia in percutaneous nephrolithotomy (PCNL). MATERIALS AND METHODS: A randomized controlled double blinded study was designed in 60 American Society of Anesthesiologists (ASA) grade I and II patients to assess & compare the impact of peritubal infiltration of bupivacaine, ropivacaine, saline with 23-gauge spinal needle along the nephrostomy tract after PCNL under fluoroscopic guidance. Patients were randomized into 3 groups B (bupivacaine), R (ropivacaine), S (saline/control). Each group containing 20 patients were given 20mL of respective drug at the conclusion of the procedure. Postoperative pain score and analgesic requirement for the first 24 hours were assessed by visual analog scale second hourly. Rescue analgesia with inj. Tramadol 2mg/kg was given intravenously to a maximum total dose of 400mg when pain score exceeded 4. RESULTS: Pain scores and analgesic requirement for the first 24 hours postoperatively were lesser in the B (bupivacaine) & R(ropivacaine) groups than in the S(saline/control) group of patients at all points of time and were statistically significant (p<0.005). CONCLUSION: In this study a significant difference in the pain scores and analgesic requirement was noted in saline and drug groups. Peritubal infiltration of 0.25% bupivacaine or 0.375% ropivacaine solutions is equally efficient in alleviating postoperative pain after PCNL.