Background: The education sector is badly shaken in the wake of COVID-19 pandemic as nationwide closures have impacted 89% of the world’s student population. Aims and Methodology: This qualitative, exploratory study investigated the impacts of COVID-19 on the prevailing education divide through focus group discussion. Focus group included purposefully selected two teachers (one male & one female), two senior headteachers (one male & one female), two Taluka Education Officers (one male & one female), two Assistant District Education Officers (One male & one female) and two Assistant professors of Education (one male one female). The focus group interviews were conducted from the participants through conference calls. Results: Focus group discussion results showed that there could be variable impacts of COVID-19 across society, parents, input that students could receive from families during this pandemic, assessment, gender, and schools. These variable impacts could result in further widening of the existing education divide in Pakistan. The major reasons, as highlighted by the participants, are the weak education system and the prevalent digital divide in Pakistan due to the use of online learning resources. It is recommended that the authorities should engage economically sound local elders, Non-Government Organizations and volunteer educated persons to meet the technology-based needs.
Introduction: Diclofenac potassium has widely been utilized as an analgesic and anti-inflammatory agent. To achieve rapid onset of action with prolonged therapeutic action is an immense need of time. In present project a study was conducted on preparation with physicochemical determination of diclofenac potassium tablets, this unique tablet have duel characteristics like rapid onset of action due to orodispersible coat and extended release of API due to sustained release core. Methodology: As diclofenac potassium is not sensitive to water so wet granulation method was efficiently employed to prepare the granules of sustained release core, while direct compression was done to prepare orodispersible outer coat layer in order to give rapid release. Results and Discussion: In evaluations granules characteristics and tablet properties were studied. Result of both pre compression and post compression studies were coming in pharmacopeia acceptable ranges. The orodispersible layer disintegrated with in 18sec, which gives sufficient amount of API as loading dose, in order to maintain the plasma drug concentration in therapeutic range the core will release drug in sustained manner within 10 hours in gastrointestinal tract (GIT) fluid (pH 6.8). The results of kinetic models were complying with Higuchi model. Conclusion: In present work, a rapid release outer dispersible layer of drug was constructed on a sustained release core. Results of study gives expected outcomes to maintained initial concentration of drug which persist for long time. The combination of sodium starch glycolate, dry starch, and cross povidone exhibited promising super disintegrant efficiency while Hydroxypropylmethyl cellulose K15 showed excellent sustained release properties.
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