Sultana Mohammed have filed a patent on aspects of this work in conjunction with Cornell University. A. A. Sauve has intellectual property related to NR and derivatives of NR. Chromadex Inc. (Irvine, CA) has a license on intellectual property related to production and uses of NR. A. A. Sauve is a consultant and a co-founder of Metro MidAtlantic Biotech LLC and Metro International Biotech LLC. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This article contains Figs. S1-S5.

A large number of benzothiazole derivatives discussed here possess potent anticancer activity and can be further developed as drug candidates. Benzothiazole conjugates could also display synergistic effect and still there is a need to use the drug combinations permitting lower dose and development of new generation of drugs. Despite encouraging results that have been observed for their response to tumor in clinical studies, full characterization of their toxicity is further required for their clinical usage as safe drugs for the treatment of cancer. We believe that this review gives a better understanding and scope for future drug design and development of benzothiazole-based compounds to implicate their use in cancer chemotherapy.