Liver dysfunction in the presence of Systemic Lupus Erythematosus (SLE) can be caused by many factors including drug-induced, SLE itself, fatty liver, Autoimmune Hepatitis (AIH), primary biliary cirrhosis, cholangitis, alcohol or viral hepatitis. However, Lupus hepatitis and autoimmune hepatitis are two distinct immunological conditions involving the liver, which can have similar clinical, laboratory and systemic presentations, leading to difficulties in diagnosis [1,2].