Folding of the mitochondrial inner membrane (IM) into cristae greatly increases the ATP-generating surface area, S IM , per unit volume but also creates diffusional bottlenecks that could limit reaction rates inside mitochondria. This study explores possible effects of inner membrane folding on mitochondrial ATP output, using a mathematical model for energy metabolism developed by the Jafri group and two- and three-dimensional spatial models for mitochondria, implemented on the Virtual Cell platform. Simulations demonstrate that cristae are micro-compartments functionally distinct from the cytosol. At physiological steady states, standing gradients of ADP form inside cristae that depend on the size and shape of the compartments, and reduce local flux (rate per unit area) of the adenine nucleotide translocase. This causes matrix ADP levels to drop, which in turn reduces the flux of ATP synthase. The adverse effects of membrane folding on reaction fluxes increase with crista length and are greater for lamellar than tubular crista. However, total ATP output per mitochondrion is the product of flux of ATP synthase and S IM which can be two-fold greater for mitochondria with lamellar than tubular cristae, resulting in greater ATP output for the former. The simulations also demonstrate the crucial role played by intracristal kinases (adenylate kinase, creatine kinase) in maintaining the energy advantage of IM folding.

Recently, different numerical studies of coarsening in disordered systems have shown the existence of a crossover from an initial, transient, power-law domain growth to a slower, presumably logarithmic, growth. However, due to the very slow dynamics and the long-lasting transient regime, one is usually not able to fully enter the asymptotic regime when investigating the relaxation of these systems toward equilibrium. We here study two simple driven systems-the one-dimensional ABC model and a related domain model with simplified dynamicsthat are known to exhibit anomalous slow relaxation where the asymptotic logarithmic growth regime is readily accessible. Studying two-times correlation and response functions, we focus on aging processes and dynamical scaling during logarithmic growth. Using the time-dependent growth length as the scaling variable, a simple aging picture emerges that is expected to also prevail in the asymptotic regime of disordered ferromagnets and spin glasses.

The identification of the characteristics that have an influence on the vaccination coverage of children and the determination of the pattern of such influence are very important since the government can reschedule the policy to immunize each and every child. This paper examines the factors that manipulate the vaccination coverage in terms of five major vaccines using the Bangladesh Demographic and Health Survey (BDHS)-2007 data. The results strongly suggest that mother's education and economic status play a vital role significantly in improving the vaccination coverage. Besides, Khulna and Rajshahi have higher whereas Sylhet and Chittagong have lower immunization coverage than Dhaka. In addition, mother's exposure to media (newspaper, TV or radio) also improves the status of coverage both in the rural and urban areas in Bangladesh.