A new series of proximicin analogues containing a benzofuran moiety as the replacement of the di-furan scaffold of the parent compound were synthesised and evaluated for their anti-proliferative activities against human glioblastoma cells U-87 MG.

Nucleosides are endogenous small molecules involved in key cellular processes and systems and are comprised of either purine (adenine and guanine) or pyrimidine (thymine, cytosine and uracil) nucleobases attached to a ribose moiety. Monophosphate-nucleosides form the backbone of nucleic acid structures storing the genetic material of a whole organism, and monomeric nucleosides function as signalling molecules both inside the cell and in the extracellular matrix (Müller et al., 2020). Following ATP hydrolysis, adenosine (ADN) acts as a ligand for the