No abstract

Targeting cap-dependent translation initiation is one of experimental approaches that could lead to the development of novel anti-cancer therapies. Synthetic dinucleoside 5’, 5’-triphosphates cap analogs are potent antagonists of eukaryotic...

All of our findings support a strategy to decrease the doxorubicin concentration in combination with SAL-O-AZT hybrid in order to reduce the toxicity of this drug, as recently demonstrated for SAL. The advantages of the SAL-O-AZT conjugate over SAL are better RI and SI parameters at similar IC50values.

Synthesis of 3'-Azido-2',3'-dideoxy-5-fluorouridine Phosphoramidates and Evaluation of Their Anticancer Activity. -The precursor for the target compounds is prepared starting from 5-fluoro-2'-deoxyuridine (I). Compounds (VI) are evaluated for their cytotoxic activity in human cancer cell lines with (VIa) showing highest activity. -(LEWANDOWSKA, M.; RUSZKOWSKI, P.; BARANIAK, D.; CZARNECKA, A.; KLECZEWSKA, N.; CELEWICZ*, L.; Eur. J. Med. Chem. 67 (2013) 188-195, http://dx.doi.org/10.1016/j.ejmech.2013.06.047 ; Fac. Chem., Adam Mickiewicz Univ., PL-60-780 Poznan, Pol.; Eng.) -R. Langenstrassen 05-203

No abstract