Uninvestigated parts of general matters defining. However, the problems related to the study of the practical aspects of state regulation of higher education system in Ukraine are still not fully solved.The research objective. The aim of this article is to ground scientific approaches to the formation of organizational and economic mechanism of higher education system regulation in Ukraine.The statement of basic materials. Ukraine inherited the Soviet model of higher education system with, in fact, the only source of funding and full regulation of educational processes. During the years of independence, the state policy in the field of higher education is characterized by consistency, focus on the development of global civilization. Liberalization of public relations effected the reforming of higher education system and its adaptation to the new economic and social situation in the country. There was a rapid increase in the number of higher education establishments with a simultaneous decline in the quality of educational services. High inflation, budget deficits and other economic factors had negative influence on higher education system funding.Quality of education reducing influenced the growth of unemployment among university graduates, reduced contingent of foreign students, the low efficiency of management solutions of the employed young professionals.Even when the Ukrainian educational system became a part of the Bologna Process, which was seen as a panacea for national education, it had not led to the synthesis and adapting of the positive European experience in the development of higher education system. Thus, none of Ukrainian universities is not included in the ranking of universities according to the groups of experts Shanghai Jiao Tong University [5]. In the QS World University Rankings in 2015/16 only six Ukrainian universities are located in four to eight hundred [6].The main characteristic features of modern Ukrainian higher education system are: -low efficiency of state regulation; -lack of development strategy and its specification; -low quality of education; -costly mechanism of state funding. New attempt to reform the higher education system was connected with the adoption of the new Law of Ukraine «On Higher Education» in 2014 [7]. Five stages of higher education: junior bachelor, bachelor, master, Ph. D, doctor of sciences had been proposed.State higher education institutions finally received the right to manage their own financial resources. In this context, according to the above mentioned legislation, the concept of «autonomy of the university» takes practical content. This term is interpreted as «autonomy, independence and accountability of higher educational establishment in making decisions regarding the development of academic freedom, organization of educational process, research, internal governance, economic and other activities, independent choice of staff within the limits prescribed by law» [7] .However, these innovations are, in our opinion, mostly forced. For example, the nee...