Objective. Monocyte chemoattractant protein-1 (MCP)-1 and soluble vascular cell adhesion molecule-1 (sVCAM-1) are key regulators of the inflammation sites infiltrated with monocytes. The aim of the study was to investigate the role of these molecules in children with asthma. Methods. The levels of MCP-1 and sVCAM-1 during asthma exacerbation on the background of therapy in children with various degrees of asthma severity as well as correlation relationships between MCP-1, sVCAM-1 and parameters of respiration function were determined. Results. The level of MCP-1 and sVCAM-1 in all groups of the examined patients at the period of exacerbation of the disease was significantly higher than in children of the control group. On the background of therapy the levels of MCP-1 and sVCAM-1were decreased in patients of all groups, regardless of asthma severity. Negative correlation relationships between MCP-1 and FEV1, PEF, VC, FVC, FEV1/FVC were revealed before and after the therapy. Conclusions. The increased levels of the abovementioned biomarkers were preserved on the seventh day of therapy. This testifies to the involvement of these chemokines into the formation and prolongation of the inflammatory process. The revealed negative correlation between MCP-1 and the main parameters of pulmonary function testified to participation of chemoattractant MCP-1 in chronic inflammation of the airways.