Background: Innate immunity is currently considered to be an important component of pathological cascade in old age dementia. The aim of this study was to evaluate activity of inflammatory markers such as leukocyte elastase and alpha-1 proteinase inhibitor, as well as concentration of C-reactive protein and interleukin-6 in blood plasma of patients with pure' AD, mixed dementia and VaD of varying severity.Methods: Several parameters of innate immunity such as leukocyte elastase activity (LE), the functional activity of α1-proteinase inhibitor, the concentration of C-reactive protein (CRP) and interleukin-6 (IL-6) were measured in blood plasma of elderly patients with main forms of dementia including: Alzheimer's disease (AD), mixed dementia (MD) and vascular dementia (VaD). Results:A total of 161 in-patients and 39 control subjects were included in the study. The levels of innate immunity markers were found to depend on the severity of dementia. The decreased activity of LE in AD and MD is suggested to be due to the alteration of neutrophils degranulation activity or to changes in enzyme properties. A negative correlation between the level of IL-6 and degree of cognitive impairment in AD (Spearman r= -0.43; p<0.05) indicates significantly that levels of proinflammatory cytokines may characterize the severity of the process having the great impact on (lower) total MMSE score. Elevated level of CRP is likely to be a biological marker of an early stage of disease in VaD. Conclusions AbstractA comparative study of innate immunity markers in Alzheimer's disease, Mixed dementia and Vascular dementia 2 ARC Publishing

The authors describe lines of drugs developed on the basis of structurally modified hyaluronic acid. They demonstrate their effect on the synthesis of collagen fibers and state of intercellular matrix. They also present the results of studies of efficacy of using these drugs for correction of involutional skin changes.

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