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Communicated by Aivars Lejnieks The paper presents information on pneumonia (P) patients with features of oxidative stress (OS

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Summary. The article presents the data of local application of a 0.02 % decasan solution in patients with traditional «open» obviously clean planned surgical interventions on the gastrointestinal tract without perioperative antibiotic prophylaxis. Objective: to provide intraoperative protection of traditional “open” clean planned surgical interventions and to achieve the prevention of purulent-inflammatory complications through local clinical use of decasan without perioperative antibiotic prophylaxis. Materials and methods. The study involved 63 patients who were treated at the clinic of the State Institution «Institute of General and Emergency Surgery named after V. T. Zaitsev NAMS of Ukraine» and operated in a planned manner regarding umbilical and inguinal hernia. He performed the traditional «open» clean surgical interventions — hernioplasty. All patients participating in the study were divided into two groups. The main group consisted of 29 (46.1 %) people who, for the purpose of intraoperative protection of the performed interventions, were locally irrigated with the cavity of the surgical wound and suture line with a solution of universal antiseptic decasan, 1 ml of which contains 0.2 mg of decamethoxin, without perioperative antibiotic prophylaxis. The comparison group consisted of 34 (53.9 %) people who underwent antibiotic prophylaxis with parenteral administration of 1.0 g cefipime during the perioperative period. Results. When conducting a preliminary bacteriological study of smears performed intraoperatively in patients in the group with clinical use of decasan by soaking all the walls of the surgical wounds (initial data before treatment with the drug), the absence of pathological microflora growth was revealed. Conclusions. It is concluded that the local clinical use of decasan in patients with gastrointestinal tract pathology when performing “open” obviously clean planned surgical interventions fully ensures their adequate intraoperative protection without perioperative antibiotic prophylaxis.