COVID-19 is a multisystemic infectious disease that primarily affects the respiratory system. However, the involvement of extra-pulmonary systems has also been reported. We report a 25-year-old female patient who visited the emergency department with a four-day history of severe burning epigastric pain associated with vomiting. The patient was later diagnosed with severe acute pancreatitis with concomitant severe COVID-19 based on clinical, biochemical, and imaging findings. The patient was managed with antibiotics, anticoagulation, and ventilatory support. Despite aggressive treatment efforts, the patient sustained cardiac arrest in the setting of refractory hypoxemia and passed away on day three of her hospitalization.