The reuse of wastewater can combine environmental preservation and high agricultural productivity, mainly by minimizing the pressure on water withdrawal. The Family Bio-water System uses domestic greywater for family farming, being an alternative for food production in the backyards of farming families in places that suffer from water scarcity. Aiming to evaluate the environmental and socio-economic sustainability of these systems, 13 units were analyzed in the rural area of the municipalities in the state of Ceará. The MESMIS method was used, based on indicators composed of Water Resources; Soil Quality; Health Situation; Work and Relationships; Economic Situation; Adaptation; Productivity; and Self-Management, as well as microbiological and physical-chemical data of the reused water. The results confirm that the systems presented good pollutant removal efficiency, with the exception of Escherichia coli, which requires attention because it presents health risks. It was evidenced that the agroecosystems are sustainable and that the integration of socio-environmental, technical, and economic criteria is relevant to support the decision-making of the families benefited by the system.