Ambroxol Hydrochlorideand Cetirizine Hydrochloride are often prescribed together for greater patient acceptability, increased potency, multiple activity, fewer side effects and quick relief. AmbroxolHydrochloride and Cetirizine Hydrochloride are used for the treatment of bronchitis, cough, and allergy. Ambroxol and Cetirizine tablet available in the market are not suitable in certain cases such as motion sickness, sudden episodes of allergic attacks, or coughing and when drinking water is not available. Particularly these types of difficulty are pediatric and geriatric patients. An attempt has been made to develop and enhance the stability of two combine drugs Ambroxol Hydrochloride and Cetirizine Hydrochloride, we prepared fast disintegration tablets. Total six formulations (F1 were prepared to study the effect of superdisintegrants shown in Table I. Tablets were prepared technique of direct compression methods quantity of each ingredient was taken for each specified formulation. The superdisintegrant, sodium starch glycolate (1%, 2%, 4%, 6%, 8%, and 10%) concentration was used to develop the tablets. All the ingredients were passed through mesh the ingredients were cogrind in a pestle motor. talc and Sodium Stearyl fumarate were added and mixed for 5 minutes. The blended excipients were compressed into tablets using tablet compression machine (Madhur Industries, India). The dissolution studied results revealed that in both of the drug Ambroxol Hydrochloride and cetirizine hydrochlori in phosphate buffer pH 6.8 and pH 7.4 dissolution medium were shown within the specified Pharmacopoeias limit.