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aneuploidy by gestational age, maternal age, and positive findings on RPL investigations. A polynomial regression model was constructed based on the relationships of these variables.RESULTS: A total of 604 miscarriages were included in the study. There was a significant relationship between the odds of aneuploidy and both maternal age and gestational age. There was a linear relationship between aneuploidy and maternal age, with a nearly 2-fold increase in the odds of aneuploidy with every 5-year increase in maternal age (OR 1.83, 95% CI 1.40-1.83). In contrast, the association between aneuploidy and gestational age was curvilinear, with a peak probability of aneuploidy with pregnancy losses at approximately 8 weeks gestation (p¼0.02). While women with positive findings on RPL investigations had a slightly lower odds of aneuploidy as compared to those with a normal work-up, this difference was minimal and did not reach statistical significance (p¼0.18).CONCLUSIONS: There is an overall high rate of aneuploidy among the RPL population, even in women with positive findings on traditional RPL investigations. Across all maternal ages, the odds of aneuploidy significantly drop in pregnancy losses over 12 weeks gestation. These findings suggest that genetic testing on POC should be offered at the time of second and subsequent pregnancy losses <12 weeks gestation to all RPL patients.