Objective: Verify the effects of intensified and usual clinical nursing monitoring on the quality of life and sedentary lifestyle of hypertensive and diabetic patients in primary care. Method: A quantitative and quasi-experimental study of time series. The sample this study consisted in 85 users allocated in control (n=45) and experimental (n=40) groups. The intervention was a nursing consultation with biochemical monitoring program. Results: With the monitoring, laboratory variables in experimental group were controlled, such as serum creatinine (0.82 – 0.79 mg/dL). The control group included 6 (26.09%) patients with renal dysfunction (p=0.001). Sedentary lifestyle was reduced in the experimental group (15.00% to 0.00%). The psychological domain of quality of life presented a better perception in the group without renal dysfunction, when compared to the users with renal dysfunction (80.8 ± 0.19 vs 51.8 ± 0.21, p=0.013). Conclusion: Results proved to be relevant for the Nursing assistance practice with reduction of sedentary lifestyle and an improvement in quality of life, the modifiable risk factors for kidney diseases.