A facile one‐pot three‐component coupling (3CC) of indoles, aldehydes, and N‐alkyl anilines has been attained using a catalytic quantity of molecular iodine under neutral conditions to afford 3‐aminoalkyl indoles at room temperature. The salient features of this method are the mild reaction conditions, the operational simplicity of the method, outstanding yields in moderately at short reaction times and low cost of the catalyst.

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We report a set of twelve rationally designed and library of perillyl-4H-pyrantriazole derivatives (6a-6l) through a sequence of a multicomponent reaction followed by copper-catalyzed cycloaddition. The intermediate 4-aryl-4Hpyran (4) was obtained by three-component condensation of 5,5-dimethylcyclohexane-1,3-dione) (1), 4-(prop-2-yn1-yloxy) benzaldehyde (2) and malononitrile (3). To this intermediate, azido benzenes (5) were subjected using copper catalyze cycloaddition to produce perillyl-4H-pyrantriazole derivatives in better to good yields. All compounds were validated by mass, 13C-NMR, FTIR and 1H-NMR spectrometry.

The development of chemical compounds that exhibit broad-spectrum antibacterial activity requires an attentive selection of chemical entities because of the fast growth of antimicrobial resistance. In this study, we analyzed 12 Perillyl-4H-pyrantriazole derivatives (6a-6l) for antibacterial activity (in vitro) on Gram +ve and Gram -ve bacteria (Staphylococcus aureus, Enterococcus, Bacillus subtilis, Salmonella, Escherichia coli, and Klebsiella). The obtained results have shown that some derivatives are potential antibacterial agents compared to a standard streptomycin drug. Additionally, molecular properties, docking studies, ADMET, and TOP KAT studies were performed for all the compounds through in silico method. Among all, the compound (6i) has shown a potential antibacterial activity along with a high Lib dock value of 184.315 Kcal/mol.

Heterocyclic chemistry has a broad spectrum of applications in our day-to-day life. Heterocyclic compounds contain hetero atoms like oxygen, nitrogen, and sulphur in their structure. Among these atoms, a wide variety of heterocyclic moieties with nitrogen as hetero atoms have considerable physiological properties and useful medical applications. Nitrogen-containing heterocyclic compounds are considered a significant category due to their broad therapeutic applications like antibacterial, antimalarial, anticancer, antifungal, anti-HIV, anti-inflammatory, etc., this review article focuses on novel moieties of indole, pyrazole, and triazole compounds and its biological importance