5-flurouracil (5-FU) is a frequently administered chemotherapeutic drug in various malignant neoplasms. We report four cases of cancer patients who were exposed to 5-FU and which resulted in cardio toxicity. Patients developed supraventricular tachycardia, sinus bradycardia, cardiomyopathy, and acute coronary vasospasms. In all cases, the events were reversible. Except in case of cardiomyopathy the chemotherapy was continued without any further issues. All the observed adverse drug reactions (ADR) were carefully studied and the causality was assessed using Naranjo ADR probability scale.

No abstract

No abstract

No abstract

for the purchase of safe sharps disposal means (i.e., self-destructive syringe, mobile sharps disposal containers, etc.) significantly reduces the cost of treatment and other types of costs to restore the medical workers' health. Data from the interviews with Kazakhstani primary care nurses indicate that 38.9% of respondents experienced a case of injury at least once, 21.7% of respondents shared their observations that they witnessed needle stick injuries to other health workers in the workplace. The majority of the respondents (91.9%) answered that they would feel safer if they had portable sharps bin system. Conclusions: To conclude, a high incidence of needle stick injuries among the nurses suggests immediate interventions. Therefore, the policy on prevention of needle stick injuries of primary care nurses would reduce government's expenditure due to the prevention of HBV and HCV infections.