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Background: Risk factor reduction is the primary clinical approach in preventing coronary artery disease. Traditional risk factors are found to be absent in many of the cases. Novel risk factorhyper homocysteinemia was reported to be associated with the disease process. Objectives: This study is aimed at identifying the association of coronary artery disease with homocysteine and other conventional risk factors, along with the risk they pose both independently and in combination. Methods: The study included 100 people, 60 subjects in the study group with diagnosed coronary artery disease & 40 subjects in the control group with no disease. Conventional risk factors are evaluated & compared along with homocysteine levels. Results: The data obtained concludes that the levels of homocysteine independently are significantly higher (20.19 ± 5.00) among the study than the control group (12.35 ± 3.39).However, there was no significant association between conventional risk factors homocysteine levels and conventional risk factors (smoking, family history of coronary artery disease, hypertension and diabetes). Conclusion: Elevated levels of homocysteine are associated with coronary artery disease. Homocysteine, in combination with the conventional risk factors, did not pose any increased risk for the disease. Raised levels of Homocysteine in the controls is probably attributed to the early sign of disease occurrence, further investigation is required into this aspect. Also, an investigation is necessary to search for the ways of reduction of risk like vitamin supplementation.

Background: End Stage Renal Disease is the common cuase of morbidity and mortality in patients suffering from diabetes and hypertension. Loss of transferrin and renal impairment in diabetic patients might lead to microcytic anaemia. Progression of nephropathy in these patients can be prevented by checking the hemoglobin levels. Objectives: This study is aimed at identifying the relationship of transferrin levels and anaemia in diabetic nephropathy. Methods: The study included 100 patients who were categorized as 20 normoalbuminuric, 40 microalbuminuric and 40 macroalbuminruic based on urine albumin levles. Serum Transferrin, Hemoglobin were measured in all the three groups. Results: The data obtained concludes that the levels of hemoglobin are significantly reduced in macroalbuminuric (9.0 + 1.61) than mciroalbuminuric (11.5 + 1.71) as compared to normoalbuminuric (13.1 + 1.91) patients. Serum transferrin levels were significantly reduced in macroalbuminuria (207 + 33.7) as compared to normoalbuminuria (263 + 51.8), which in correlation to hemoglobin levels. Conclusion: Anaemia was often seen at an early stage in diabetic nephropathy than in patients with chronic kidney disease. It is, therefore, crucial to monitor anaemia to prevent the progression of renal disease in diabetic patients manifested as microalbuminuria. Plasma transferrin levels are decreased in macroalbuminuria though the synthesis is increased in diabetic nephropathy as the response doesn't compensate for the loss of transferrin in the urine. Further understanding of the mechanism and providing the therapy may improve patient outcomes.

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