No abstract

Introduction:The dissemination of tumour cells to the brain parenchyma does solely occur via the blood stream, as the brain lacks lymphatic vessels. Therefore, tumour cells have to manage survival and adapt to the changed microenvironment within the bloodstream. Several preclinical studies indicate that tumour cells might aggregate with platelets and leucocytes in order to survive. Methodology: This study was performed at the Department of Radio-diagnosis, and the patients selected for the study were referred from Neurosurgery/Neurology OPD or Emergency department at our hospital, who were clinically suspected to have a space occupying lesion or having history suggestive of metastases. The patients presented with symptoms like headache, motor weakness, diminished vision, double vision, seizure. All patients were seen by appointment, except for the emergency cases. Relevant history of illness and significant clinical findings of all patients were recorded. Results: Out of 50 cases adenocarcinoma (66%) was the most common histopathology metastasized to the brain followed by squamous cell type (16%), Melanoma (6%), GBM (2%), Oligodendroglioma (2%), liposarcoma (2%) and choriocarcinoma (2%). Conclusion: In our study most common primary site of metastases was from lung (60%), site of origin of primary was not identified in the 10% cases, third common primary was from breast (6%), kidney (6%), Melanoma(6%) followed by brain (2%), thyroid(2%), Cervix (1%) and uterus(1%).

Introduction: The radiological imaging plays a primary role to detect, localize, and diagnose the lesion. Various modalities which can be used are radiography, Computed imaging, Magnetic resonance imaging, Nuclear medicine and angiography. Except MRI, all other modalities involve exposure to radiation. Methodology: Fifty (n = 50) patients, who underwent surgery with histopathological diagnosis were included in the study. Written informed consent was obtained from all the patients for the study. Detailed clinical history was taken in all the patients. Results: Intraaxial was the most common compared to the extra axial location. Supra tentorial was most common than infra tentorial. Skull vault involvement was seen in 10% cases and dural metastases were seen in 18% cases. Conclusion: Brain metastasis is common among patients with systemic cancer. Brain metastasis (MET) is thought to occur when the primary tumor acquires the ability to migrate away from the primary site and travels to the brain.