New succession related to the transition metal complexes Cu(II), Ni(II), and Co(II) with 4-((Z)-4-bromobenzylidene)-2-(7-((4bromobenzylidene)amino)-3methyl-8oxo-5-thia-1azabicyclo[4.2.0]oct-2-en-2yl)oxazol-5(4H)-one) has been prepared and described. The structural descriptions have been reached from FT-IR, UV Vis-Spectrophotometer, molar conductance measurements, magnetic susceptibility, atomic absorption techniques as well as 1 HNMR. Based on these results, it is proposed that the coordinates of the ligand to metal ions from the nitrogen related to azomethine group as well as the oxygen of carbonyl group. In addition, the biological activity of the complexes and the ligand has been investigated opposite Staphylococcus aureus, Aspergillus Niger, E.coli, and Candida albicans. The products indicate that Co (II)-complex, Ni (II)-complex and Cu (II) -complex is the enhanced biological activity in comparison to the ligand.

A novel derivative of 2,3-disubstituted quinazolin4(3H)-ones has been produced as of p-methoxybenzoylchloride and anthranilic acid, this prepared compound was used to produce a stable complexes. The ligand and complexes were isolated from the reaction in the solid form and characterized by FT-IR, UV-Visible, TLC, 1H NMR data and some physical measurements. Magnetic susceptibility data coupled with electronic spectra suggested octahedral structure of the complexes. The ligand and complexes were also employed with various bacterial. The products exhibited that the metal complexes have larger antimicrobial activities than ligand.