Wind and earthquake loadings are the two major types of lateral dynamic excitations experienced by high-rise buildings. An efficient design must ensure the safety of structural and non-structural components of a building against both types of loadings. This study evaluates the seismic performance of high-rise buildings primarily designed based on different levels of lateral wind loads. A 40-story dual system case study building is selected for this purpose. In dual systems, the lateral load is mainly resisted by a combination of reinforced concrete core wall and the special moment resisting frame. The case study building is assumed to be located in a moderate-level seismic zone and is separately designed for wind loading using three different levels of wind speeds (low, moderate and high), which are selected to represent the anticipated hazards at various global wind zones. The detailed seismic performance exhibited by three different design cases (corresponding to different levels of wind hazard) is evaluated. The Nonlinear Response History Analysis (NLRHA) procedure is used to obtain the true inelastic seismic demands and to compare the seismic performance of all three design cases. The results showed that the level of design wind load can alter the seismic performance of high-rise dual system buildings. Therefore, even for the cases where the wind demands control the design of lateral load-resisting system, the detailed performance-based seismic evaluation should be carried out to ensure the overall structural safety and integrity.