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In equine clinics, skin injuries are some of the most frequently treated injuries, this research evaluated the healing potential and antioxidant activity of Abarema cochliacarpos in order to develop a pharmaceutical formulation for treating skin lesions in horses. Firstly, the antioxidant activity of several fractions was evaluated using the 2,2-diphenyl-1-picrylhydrazyl radical method and the thiobarbituric acid test. The determination of phenolic compounds was done by means of the Folin-Ciocalteau test. To assess the wound healing activity the dry powdered stem bark and the aqueous, ethanolic and propylene glycol extracts from the same plant, material were incorporated in a gel formulation and evaluated in equines with induced wounds. Results show that all obtained extracts and their fractions have antioxidant action. Regarding the healing evaluation in equines, the extracts tested and the dry powdered stem bark showed statistically significant activity in the contraction of wounds. Histological analysis revealed the powdered stem bark as the best treatment to induce healing of cutaneous lesions in horses. Experimental studies in animals with different dosages and formulations, besides the isolation of its chemical components, as a tool in the discovery of new healing agents or optimization of the existing ones is recommended.

This study aimed to evaluate the application of thermosonication for the viability of Staphylococcus aureus and the antioxidant activity of HM. The US effect on the S. aureus was measured by counting viable cells in discarded HM immediately before and after different treatments varying time (1, 5 and 10 minutes) and temperature (20, 30, 40, 50 and 60 °C) through surface plating on standard agar. The antioxidant activity evaluation was carried out by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) scavenging method. With Regarding microbiological quality, it can be concluded that treatment with US at 60 °C for 10 minutes was the most effective in terms of reducing the viability of S. aureus, in addition to presenting a significant increase in the content of antioxidants when compared to raw and pasteurized milk samples.

O corante caramelo tem sido amplamente utilizado em alimentos e bebidas e é regulamentado globalmente como aditivo químico. As quatro classes distintas do corante caramelo (caramelo simples (I), caramelo sulfito (II), caramelo de amônia (III) e caramelo sulfito-amônia (IV)) são bem caracterizadas e cada uma tem especificidades que variam com os tipos de processamento do composto, especialmente a adição de reagentes que podem dar origem a compostos de baixo peso molecular, como por exemplo, o 4-metilimidazol, subproduto do caramelo IV, que pode ter significativo efeito toxicológico. Tendo em vista o elevado consumo de alimentos industrializados e a potencial exposição em longo prazo desse composto, em diferentes faixas etárias, o objetivo desta revisão foi resumir os estudos mais relevantes disponíveis nos últimos 5 anos sobre os efeitos tóxicos do 4-metilimidazol, nas bases de dados PubMed, Science Direct e Lilacs. Os resultados dos estudos avaliados são divergentes e os mecanismos de toxicidade ainda não estão bem elucidados, apesar de alguns estudos terem encontrado efeitos negativos à saúde com a exposição ao 4-metilimidazol, tornando-se relevante novos estudos para esclarecer a sua real segurança.

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