Objectives:to estimate the incidence of dry eye, to identify risk factors and to establish a risk prediction model for its development in adult patients admitted to the intensive care unit of a public hospital. Method:concurrent cohort, conducted between March and June, 2014, with 230 patients admitted to an intensive care unit. Data were analyzed by bivariate descriptive statistics, with multivariate survival analysis and Cox regression. Results:53% out of 230 patients have developed dry eye, with onset mean time of 3.5 days. Independent variables that significantly and concurrently impacted the time for dry eye to occur were: O2 in room air, blinking more than five times per minute (lower risk factors) and presence of vascular disease (higher risk factor). Conclusion:dry eye is a common finding in patients admitted to adults intensive care units, and care for its prevention should be established.
In the present study, the protective potential of Saccharomyces cerevisiae strain UFMG A-905 was evaluated in a murine model of acute ulcerative colitis (UC). Six groups of Balb/c mice were used: not treated with yeast and not challenged with dextran sulphate sodium (DSS) (control); treated with S. cerevisiae UFMG A-905 (905); treated with the non-probiotic S. cerevisiae W303 (W303); challenged with DSS (DSS); treated with S. cerevisiae UFMG A-905 and challenged with DSS (905 + DSS); and treated with S. cerevisiae W303 and challenged with DSS (W303 + DSS). Seven days after induction of UC, mice were euthanised to remove colon for enzymatic, immunological, and histopathological analysis. In vivo intestinal permeability was also evaluated. An improvement of clinical manifestations of experimental UC was observed only in mice of the 905 + DSS group when compared to animals from DSS and W303 + DSS groups. This observation was confirmed by histological and morphometrical data and determination of myeloperoxidase and eosinophil peroxidase activities, intestinal permeability and some pro-inflammatory cytokines. S. cerevisiae UFMG A-905 showed to be a potential alternative treatment for UC when used in an experimental animal model of the disease.
Objetivo: Identificar na literatura publicações sobre os fatores de risco para o olho seco em pacientes internados em unidade de terapia intensiva de adultos. Método: Realizou-se busca nas bases de dados MedLine, CINAHL, Web of Knowledge, LILACS, Cochrane, IBECS e BDENF. Foram identificadas 620 publicações potencialmente elegíveis para inclusão nesta revisão, selecionando-se ao final vinte e sete publicações que atenderam aos critérios de inclusão. Essas foram analisadas por dois pesquisadores independentes, usando-se instrumento adaptado para verificar o nível de evidência. Resultado: Foram identificados 39 diferentes fatores de risco para olho seco, sendo que os apontados em 50% ou mais dos estudos, o lagoftalmo (85,18%), uso de sedativos (70,37%), ventilação mecânica (66.66%) e uso de bloqueadores musculares (55,55%). Conclusão: Foi encontrado somente um estudo que abordasse especificamente o problema do olho seco em pacientes críticos; estudos clínicos são necessários, a fim de se apresentar evidências científicas fortes ao problema.
Objetivo: identificar o efeito do filme de polietileno na prevenção de olho seco em pacientes críticos internados em unidade de terapia intensiva para adultos. Metodologia: estudo de revisão sistemática, guiada pelas recomendações do PRISMA. foram identificados 784 estudos primários, avaliados 35 e selecionados quatro, nos quais houve referência à utilização do filme de polietileno para a prevenção de olho seco. Observou-se discreta superioridade na efetividade do filme de polietileno em relação às demais intervenções. Conclusão: as evidências não foram suficientes para afirmar se a eficácia do filme de polietileno é superior às outras intervenções. Sugere-se realização de ensaio clínico randomizado para verificar a eficácia de diferentes intervenções de enfermagem na prevenção de olho seco em pacientes críticos.Descritores: Síndromes do Olho Seco, Unidades de Terapia Intensiva, Enfermagem. POLYETHYLENE FILM EFFECTIVENESS IN DRY EYE IN CRITICAL PATIENTS PREVENTION: SYSTEMATIC REVIEWObjective: To identify the effect of polyethylene film on the prevention of dry eye in critically ill patients admitted to an adult intensive care unit. Methodology: A systematic review study, guided by PRISMA recommendations. Seven databases were searched through strategies that involved the cross-referencing of Dry Eye Syndromes, Keratoconjunctivitis Sicca, Corneal Diseases, Risk Factors, Intensive Care Units, Hospital and Nursing. Results: A total of 784 primary studies were identified, 35 were evaluated and four were selected, with reference to the use of polyethylene film for the prevention of dry eye. There was a slight superiority in the effectiveness of the polyethylene film in relation to the other interventions. Conclusion: The evidence was not sufficient to establish whether the efficacy of the polyethylene film is superior to that of other interventions.We suggest performing a randomized clinical trial to verify the efficiency of different nursing interventions in the prevention of dry eye in critically ill patients.Descriptors: Dry Eye Syndromes, Intensive Care Units, Nursing. EFICACIA DE LA PELÍCULA DE POLIETILENO EN OJO SECO EN CRÍTICO PACIENTES PREVENCIÓN: REVISIÓN SISTEMÁTICAObjetivo: Identificar el efecto de película de polietileno para evitar que el ojo seco en pacientes en estado crítico en la unidad de cuidados intensivos para adultos. Metodologia: estudio de revisión sistemática, guiándose por las recomendaciones PRISMA.Se llevó a cabo la búsqueda en siete bases de datos a través de estrategias que implican el cruce de descriptores: Dry Eye síndromes, queratoconjuntivitis seca, enfermedades de la córnea, factores de riesgo, unidades de cuidados intensivos, del hospital y de enfermería. Resultados: Se encontraron 784 estudios primarios identificados, evaluados y seleccionados de cuatro 35 en la que se hizo referencia a la utilización de una película de polietileno para la prevención del ojo seco. Hubo una ligera superioridad en la eficacia de la película de polietileno en relación con otras intervenciones. Conclus...
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